The station is one of the largest in the entire prefecture. It connects several train lines and has a vast bus terminus. It is an archetypal elevated train station. One of the train lines is the Kawagoe (川越) Line, in which Misaki City is a stop between Ōto and Aomae (青前).
Misaki City Station was used as the final destination for Dantalion's "experiment". His Rinne Domino was using it as their base of operations. The station was subsequently destroyed and had to be rebuilt.
- In Viz Media's translation of the thirtieth manga chapter, Misaki Station's sign was mistranslated as "Osaki Station".